Medicine through biographies. Veselkin Pyotr Nikolaevich (1904 – 1984) – outstanding Russian pathophysiologist, grandson of prominent Russian pathophysiologist P.M

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Veselkin Pyotr Nikolaevich (1904 – 1984) – outstanding Russian pathophysiologist, grandson of prominent Russian pathophysiologist P.M. Albitsky, pupil of N.N. Anichkoff and L.R.Perelman. He gradiuated from the Military Medical Academy and worked at the Institute of Experimental Medicine in Leningrad. He is the founder of the modern doctrine of fever and pyrogens, and predecessor of the modern concept of cytokine regulation in acute phase response. P.N. Veselkin was a teacher of academician Helena A. Korneva and other outstanding pathophysiologists.

Dinarello, Charles – (born 1943 in Boston, MA), American pathologist, internist and pediatrician, professor of Medicine in the University of Colorado at Denver. He is an expert on inflammatory and febrile cytokines, specifically Interleukin-1 (IL-1). Dinarello received his M.D. degree in 1969 at Yale University, and his clinical training at the Massachusetts General Hospital, being a pupil of Sheldon M. Wolff, a prominent clinician. From 1971 to 1974, he was a clinical associate and from 1975 to 1977 a senior investigator at the National Institute of Health in Bethesda. Dr. Dinarello has published over 450 original research articles. The Institute for Scientific Information lists him as the world's third most cited life scientist. He is considered to be one of the founding fathers of cytokine regulation doctrine, having purified and cloned IL-1. This important step established the validation of cytokines as mediators of disease, particularly of inflammation, acute phase response, immune response and fever. Dinarello’s recent studies on blocking IL-1 in humans (anti-cytokine therapy) support pivotal contributions to cytokine network understanding and to the pathogenesis of inflammatory diseases.