Now complete these sentences using words from the completed mindmap

Examiner: Let’s talk about thrombosis. What can be generated in vivo and in vitro,

and what can be generated only in a cardio-vascular system?

Student: Well, a 1………. can be generated in vivo and in vitro, whereas a

2.………. can be generated only in a cardio-vascular system.

Examiner: What are the stages of thrombosis?

Student: They are 3………., 4………. and 5………..

Examiner: A component of which complex pathologic process is thrombosis?

Student: It is a component of such processes as 6………. and 7………..

Examiner: What happens a fter a blood vessel injury?

Student: The Von Willebrand factor from the injuried endotheliocytes functions as an adhesion bridge between subendothelial collagen and the Ib glycoprotein platelet receptor (primary reversible 8……….).

Examiner: As we know,calcium ions hold the assembled components together and are essential for the reaction. What happens in this situation?

Student: The activated f. Xa then becomes the enzyme part of the second adjacent complex in the 9………. cascade, converting the prothrombin (f. II, substrate) to 10………. (f. IIa) in cooperation with the reaction accelerator f.Va. Thrombin converts 11………. to 12………. within and around the platelet plug, essentially cementing the platelets in place.

8 Complete each sentence by choosing the best ending from the list a – g below.

1. A thrombus consists of plasma proteins and blood cells…

2. A clot may be generated in vivo and in vitro …

3. Thrombosis is one of the components…

4. Congenital deficiencies in various receptors, or in bridging molecules…

5. Calcium ions hold the assembled components together…

6. The activated f. Xa then becomes the enzyme part of the second adjacent complex in the coagulation cascade…

7. Thrombin converts fibrinogen to fibrin within and around the platelet plug…

a) essentially cementing the platelets in place.

b) and are essential for the reaction.

c) whereas a thrombus may be generated only in a cardio-vascular system.

d) converting the prothrombin (f II, substrate) to thrombin.

e) primarily attached to the injured inner surface of the blood vessel or heart cavities.

f) lead to Glanzmann thrombasthenia, to Bernard-Soulier syndrome, or to von Willebrand disease.

g) of tissue response to injury.